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These groups received intravenous treatments of oridonin, orid-liposome, orid-liposome-MAL, and TLR2 pep-orid-liposome at a dosage of 5 mg/kg (equivalent to the active ingredient of oridonin), with PBS serving as the control, administered every other day

doi: 10.1016/j.bcp.2022.114989 201 RidnourLAChengRYKedeiNSomasundaramVBhattacharyyaDDBasudharDet al

Serious but rare reactions: Difficulty breathing or tightness in the chest due to hypersensitivity (extremely rare)

Based on the results of this hypothesis-generating study, the approach to patients with ASCVD and New York Heart Association functional class II-III heart failure due to ischemic heart disease should generally follow the algorithm for patients with ASCVD at very high-risk on statin therapy for secondary prevention, with the exception that no recommendation can be made for the use of a PCSK9 mAb at this time (see Figure 2A)