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642,643 These results suggest that NNMT is an appealing target for obesity and type 2 diabetes treatment

Patients who cannot afford brand-name drugs or whose insurance does not cover them may explore compounding pharmacies as a more affordable alternative

Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB, Thompson CB

These include inhibition strategies of NAD + consuming enzymes, such as CD38 and PARPs, or modulation of key NAD + synthesis proteins such as NAPRT and NAMPT, as summarized below and in Fig