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Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics The concomitant use of opioids with other opioid analgesics, such as butorphanol, nalbuphine, pentazocine, may reduce the analgesic effect of hydrocodone bitartrate and acetaminophen tablets and/or precipitate withdrawal symptoms

We describe these only as research context: the studies are conducted in laboratory and cell-culture systems, and nothing here should be read as a statement of effect in humans

That is normal and expected at this introductory level