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These peptide hormones mediate their biological actions through five different but closely related G-protein coupled melanocortin receptors (MC1-R to MC5-R) that are distributed in many tissues and involved in the regulation of important physiological functions including skin pigmentation, steroidogenesis, energy homeostasis, sexual function, and exocrine secretion (Yang, 2011)

Together, these experiments support the concept that NAD + levels could be a target to maintain oocyte numbers in the context of chemotherapy treatment