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Since GSTO1 has been known to cause de-glutathionylation of -actin impeding its polymerization into filamentous actin 11 , such a downregulation of molecules involved in cytoskeleton organization and adhesion is particularly interesting

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SCFAs inhibit the NFB pathway and reduce the production of pro-inflammatory cytokines such as IL-1, IL-6, and TNF-, which can alleviate skin symptoms in psoriasis, acne, or HS (169)

Possible reasons include Type 1 diabetes diagnosis, advanced Type 2 diabetes with severely depleted beta cells, contraindication to GLP-1 drugs (thyroid cancer history, pancreatitis history), insurance or cost barriers, prior GLP-1 intolerance, or very high blood sugar requiring immediate insulin coverage