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The intrathecal administration of HGF also exerts positive functional recovery and protection of myelinated areas in animal models of SCI (Kitamura et al., 2011)

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Limitations of oral supplementation: Poor and unpredictable absorption of Vitamin B12 Patient non-compliance due to long duration of treatment High cost of therapy without assured results Limitations of parenteral supplementation: Painful and inconvenient, leading to patient non-compliance Time consuming & inconvenient clinic visits for the administration High cost of therapy Oral is not absorbed well

Juglone has been found to be cytotoxic in cell lines at even 20 M concentrations