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Instituto de Salud Carlos III (ISCIII) Fondo de investigacin Sanitaria/Fondo Europeo de Desarrollo regional (FEDER) (PI20/00744, PI22/00469, PI22/00050, PI21/00251, PI23/00627), ERA-PerMed- JTC2022 (SPAREKID AC22/00027), SIGNAL (AC22/00028), RICORS program to RICORS2040 (RD21/0005/0001) funded by European UnionNextGenerationEU, Mecanismo para la Recuperacin y la Resiliencia (MRR) and SPACKDc PMP21/00109, FEDER funds, COST Action PERMEDIK CA21165, supported by COST (European Cooperation in Science and Technology)