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Clinically, strategies aimed at modulating EAAC1-mediated cysteine transport and boosting endogenous GSH synthesis may hold promise for mitigating post-ischemic neurodegeneration and cognitive deficits associated with vascular dementia

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Pixel quantification of images was achieved using Image J and statistics were performed using Prism 5 and InStat v.3.05

Upon recovery and expansion, a number of clonal cell lines were generated and initially screened for complete 2 -adrenergic receptor knockout by qPCR followed by additional functional validation via insulin secretion and radioligand binding assays