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The increases in their expression can impact AR in a variety of manners, including stabilization of AR mRNA through RNA-RNA hybridization (ARLNC1 [117]), absorption of miRNAs (plncRNA-1 [118]), facilitation of mRNA splicing (PRKAG2-AS1, HOXC-As1 [119]), interference with epigenetic control over AR target genes (SOCS2-AS1 [120]), preventing AR degradation (HOTAIR [121]), regulating its binding to chromatin (PCAT1 [122]) or binding to AR and thereby enhancing its transactivation (PCAT8, PCGEM1 [123])

Once acyl-carnitine is inside the mitochondrial matrix CPT II separates it into L-carnitine and acyl-CoA

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Diarrhea and flatulence Indigestion can cause diarrhea or flatulence, often made worse by excess fat or too little fiber in the diet