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Pigment epithelium-derived factor (PEDF), the overexpression of which upregulated GPX4 and FTH1 that proved to suppress LPO and ferroptosis induced by NaIO 3 , was recently viewed as an upstream regulatory molecule of RPE ferroptosis (86)

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(9) Elena M Khvatova, Victor N Samartzev, Pavel P Zagoskin, Igor A Prudchenko, and Inessa I Mikhaleva (2003) Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia Peptides, 2003 Feb, Volume 24 (Issue 2), Pages 307-11