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Whilst the quantities are minuscule and generally harmless, individuals with impaired kidney function may theoretically have reduced capacity to eliminate this cyanide with very high doses over extended periods, though this remains largely theoretical at normal supplemental doses

however, some individualsespecially those on certain diets or medicationsmay struggle to absorb sufficient B12 from food alone

Many people with a deficiency describe deep fatigue, including an "afternoon crash." With infrequent dosing, blood levels can peak and then taper before the next visit

Use protecting storage containers which are inert and airtight to protect the peptides from degradation because of exposure to mild, moisture, or contaminants