The STEP and SURMOUNT trials established GLP-1 monotherapy efficacy, while emerging data on GIP/GLP-1 co-agonists (tirzepatide) shows enhanced weight loss compared to GLP-1 alone
iScience 23 , 101761 (2020)
This wide approach might be useful as a large number of the concomitant diseases with heart failure might be the key for the therapeutic effects [77,78,79], as the stable gastric pentadecapeptide BPC 157 pleiotropic effect belongs to the cytoprotective class of agents (for review, see, i.e., [2,3,4,5,6,7,8])
Single-point energies were calculated on the optimized geometries using the B97X-D hybrid functional 87 and the 6-311 + G(2d,p) basis set with ultrafine integration grids for the QM part and the ff14SB, gaff2 and TIP3P force fields for the MM part (protein, substrate and water, respectively) with electrostatic embedding