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These factors include age, sex, existing comorbidities, targeted symptoms, blood biomarkers, and specific treatment protocols, before fully endorsing the use of omega-3 PUFAs either as an independent treatment or in conjunction with other medications for migraine management (80)

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Cycle guidelines Cycle guidelines Approach Phase 2 reference Duration 48 weeks Review Point Every 4 weeks at each dose step Best For Matches the original NEJM trial structure Approach Phase 3 TRIUMPH reference Duration 68-72 weeks Review Point Every 4 weeks