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Response: We appreciate the additional information provided by the commenters regarding the clinical activities associated with CA023
without it, they remain inactive
A deficiency can occur for several reasons, such as pernicious anemia (a condition where the body cannot absorb vitamin B12 from the diet), certain medical conditions (e.g., Crohn's disease, celiac disease), surgical removal of part of the stomach or intestine, or strict vegetarian/vegan diets if not adequately supplemented
No se localizaron datos farmacocinticos humanos confiables (vida media, biodisponibilidad) ni un conjunto riguroso de seguridad o toxicologa humana en la literatura indexada
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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