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Oralrespiratory axis Although oral microorganisms can also influence respiratory health through systemic routesincluding LPS dissemination, outer membrane vesicles, and pro-inflammatory cytokines entering the circulationthe defining feature of the oralrespiratory axis is the direct physical translocation of oral microbiota into the lower airways via microaspiration 192

Microglia with depleted GSH have an exacerbated ROS/RNS production, elevated pro-inflammatory cytokine release, impaired phagocytic clearance, and increased neurotoxic output (Matoba et al., 2023)

PLoS ONE 9:e100897

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