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Differences in pharmacokinetic profiles among GLP-1 RAs may also contribute to variability in GI tolerability, with longer-acting agents generally associated with more persistent, though often less intense, symptoms compared with short-acting formulations

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Given our observations, further studies of longer duration are warranted to clarify whether administration of metformin 3060 min before meals could improve postprandial and overall glycaemic control in type 2 diabetes

As the population of long-term GLP-1 users grows into the tens of millions, the market for these solutions will expand accordingly