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Cotadutide produced greater improvement in liver histology, including reductions in steatosis, inflammation, and fibrosis relative to cohorts treated with liraglutide, in mice with experimental NASH after similar degrees of weight loss [42]
Current research investigating potential advantages beyond glycaemic regulation and weight reduction, including impacts on non-alcoholic fatty liver disease, cardiovascular outcomes, and renal protection, may broaden the therapeutic uses of these medicines
Common signs include: Excessive worry or fear Restlessness or feeling on edge Difficulty concentrating Irritability Sleep disturbances One patient said, This shows how important it is to keep an eye on anxiety and talk to your doctor about it
The researchers behind the review found that, on average, across both trials, participants lost 10% or more of their skeletal muscle over 68 to 72 weeks
