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Dr Noluthando Nematswerani, chief clinical officer at Discovery Health, said the GLP-1 agonists (Ozempic, Trulicity, Victoza, Mounjaro, Soliqua) registered by SAHPRA for the treatment of type 2 diabetes are covered under certain conditions

Symptoms often fluctuate during dose escalation, meaning you could experience both constipation and diarrhoea

Oxyntomodulin has been studied for decades as a potential obesity treatment but was limited by poor pharmacokinetics and the need for multiple daily injections

Given these fundamental differences, you're probably starting to see why asking, "can I reconstitute tirzepatide with normal saline?" leads to a very specific, cautious answer