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All groups showed a decrease in mean HbA1c by week 12, with higher doses of LY demonstrating statistically significant placebo-adjusted decreases of up to 1.56%

Preclinical evidence supports the role of GLP-1RAs in alleviating neuropathic pain through the modulation of microglial activity, inflammatory cytokine production and -endorphin release [63, 65, 68, 70,71,72,73,74]

doi: 10.3389/fimmu.2026.1823915 Received 05 March 2026 Revised 07 April 2026 Accepted 20 April 2026 Published 29 April 2026 Volume 17 - 2026 Edited by Hao Wang, Zhengzhou University, China Reviewed by Yi Zhang, Shanghai Jiao Tong University, China Sudhir Varma, Ajman University, United Arab Emirates Updates Copyright 2026 Li, Sun, Xie, Li, Guo and Lan