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If left unattended, the deficiency can lead to anemia, as well as nerve and brain damage, which may eventually become irreversible

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[1] It is suggested that delayed processing of secreted lipids in the interfollicular epidermis and between the corneocytes in the upper parts of the hair follicles may be the cause of an impairment in the permeability of the epithelial barrier/Lipid Lamellae

Improvement with progesterone withdrawal or suppression: Resolution or marked improvement of symptoms after: Stopping progesterone containing medications Suppressing ovulation (and therefore progesterone production) This response strongly supports progesterone hypersensitivity