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A study published in the New England Journal of Medicine this month found Zepbound outperformed Wegovy in a head-to-head clinical trial

IBS-M and IBS-U: Balancing the Fluctuations Those with mixed (IBS-M) or unclassified (IBS-U) symptoms face the challenge of alternating between extremes

Researchers optimizing their protocols should track: Body composition: Use DEXA scans, bioimpedance devices, or at minimum waist/hip measurements to distinguish fat loss from lean mass loss Resting heart rate: Particularly important with retatrutide due to the glucagon-mediated heart rate increase Blood pressure: Both peptides lower blood pressure, which is beneficial but can cause dizziness if the drop is too rapid Fasting blood glucose: Especially relevant for those managing pre-diabetes or type 2 diabetes Liver enzymes: For anyone with suspected or confirmed fatty liver disease Energy levels and sleep quality: Subjective but important indicators of protocol tolerance The GLP-1 progress tracking tools available through SeekPeptides help members monitor these metrics systematically rather than relying on memory or sporadic tracking