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The half-lives of unbound IGF-1, IGF-1 in a binary complex, and IGF-1 in a ternary complex are less than 10 minutes, 25 minutes, and more than 16 hours respectively meaning that IGF-1 activity is tightly regulated by its binding proteins

This research was funded by the Spanish Ministry of Science and Innovation, Interministerial Commission for Science and Technology (CICYT - project RTI2018-095658-B-C33) and Centre for the Development of Industrial Technology (CDTI CIEN program, projects GLOBALVITI and CAVAWINNER).

NAD+ therapy is provided only after medical consultation by a licensed provider