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However, considering the existing constraints in clinical gout management and the paucity of research regarding both the involvement of BA abnormalities in gout progression and the therapeutic efficacy of BA-targeted interventions, it is imperative that future studies should aim to elucidate the underlying molecular mechanisms of BA metabolism in gout

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Statistical significance was determined by One-Way ANOVA followed by Dunnett multiple comparison test ( b and c ) and Two-Way ANOVA with dk multiple comparison test ( e and f ), with significance indicated by asterisks (*P 0.9999 for V214A in panel b (amplitude)