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As utilization continues to expand in 2026, plan sponsors will need thoughtful strategies that balance clinical value with financial stewardship

After 10 d of culture, neurons were treated with AEF0117 (0 M, 10 M, 30 M and 100 M) or staurosporine (100 nM, used as a reference compound) and a soluble fluorescent cytolysis marker

34,35 Accumulation of reports have demonstrated that IR is a complex metabolic disorder with integrated pathophysiology

These include action potential production in excitatory tissues used for cell adhesion and interactions, neurotransmitter utilisation in cell signalling such as dopamine, choline and GABA and the calcium uptake and retention regulation by synaptosomes