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This is precisely what happens in living organisms

Given that the two major defects in type 2 diabetes are insulin resistance and impaired insulin secretion, metformin is recommended for use in combination with insulin secretogogues and even with intensive insulin therapy [1]

Both peptides remain research tools, and substantial clinical investigation would be required before any therapeutic applications could be considered

Key safety observations from available trial data include: Elevated resting heart rate in a dose-dependent manner Gastrointestinal adverse effects (nausea, vomiting, diarrhoea) as the most common side effects, consistent with the GLP-1 receptor agonist class [1] [3] No clinically significant QT interval prolongation was reported in available data, though the extent of formal thorough QT assessment has not been fully detailed in published sources