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Most effects are temporary and manageable under supervision

Although individuals with obesity often exhibit greater muscle mass compared to those with normal body weight, their muscle quality is generally lower due to factors such as relative weakness and reduced mobility [15, 96]

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However, the observations that knockout of gutderived GLP1 affects glucose handling, but not food intake or body weight (Song et al., 2019), and that the GLP1 receptor antagonist exendin(939) (Ex9) did not affect food intake in human volunteers (Melhorn et al., 2014