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As an endocrine cell distributed at the intestinal epithelium, enterochromaffin cells are capable of delivering 5-HT, also known as serotonin, which exerts a delicate and complex physiological effect on bone remodeling ( Bacteroides catabolize the metabolized estrogen into a deconjugated active form, reabsorbing it through the enterohepatic circulation ( It is well known that the biogenesis of bone is highly dynamic, with the process of bone resorption showing evident circadian rhythmicity ( Melatonin (MLT), a crucial endogenous hormone whose synthesis takes Trp as raw material, was also observed to influence bone health while linking with intestinal microecology

Their conserved roles in modulating photosynthetic stability, antioxidant defense, and root plasticity highlight their importance as central mediators of abiotic stress adaptation