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The neurochemical effects of GLP-1 medications on reward pathways appear to be dose-dependent and reversible

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of injectable medications primarily used to manage type 2 diabetes mellitus and, in some formulations, chronic weight management

PMID: 40 MatsuoKNambuTMatsudaYKanaiYYonemitsuSMuroSet al

In AWARD-10 [31], a 24-week, randomized, double-blind, placebo-controlled trial evaluating once-weekly dulaglutide (administered at either 1.5 or 0.75 mg) as add-on therapy to SGLT2is in a total of 424 patients with inadequately controlled T2DM, only one episode of severe hypoglycemia was reported throughout the study, in a patient treated with dulaglutide 0.75 mg, confirming the very low incidence of serious hypoglycemia with GLP-1RAs in combination with SGLT2is [31]