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25 A more recent Cochrane review of the pharmacologic treatment of low back pain (also not specific to lumbar spinal stenosis) found that NSAIDs, muscle relaxants, and opioids had a small effect on pain reduction, but use of muscle relaxants and opioids was complicated by a significant risk of adverse effects

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This SS linkage, together with the added N-terminal tyrosine, may support resistance to acidic gastric pH and proteolytic enzymes, thereby supporting oral bioavailability

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