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[176] Prolonged elevations of brain temperature above 40 C likely promote the development of amphetamine-induced neurotoxicity in laboratory animals by facilitating the production of reactive oxygen species, disrupting cellular protein function, and transiently increasing bloodbrain barrier permeability

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Identified through a yeast two-hybrid assay, BRWD3 knockdown strongly attenuated light-dependent cry degradation in S2 cells (Ozturk et al., 2013)