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A randomized, controlled study evaluating effects of amlodipine addition to chelators to reduce iron loading in patients with thalassemia major

This recommendation should be individualized, particularly for patients with kidney disease

The enzymatic activity of prolyl 4-hydroxylase subunit alpha 1 (P4HA1), a procollagen-proline, 2-oxoglutarate 4-dioxygenase, is crucial for collagen polypeptide chain folding into stable triple-helical molecules and consequently for ECM deposition [23]