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Emerging treatments, such as the use of GLP-1 analogs like semaglutide, have shown promising results in improving symptoms and physical limitations in the setting of comorbid heart failure with preserved ejection fraction and obesity

This seems counterintuitive but relates to metabolic efficiency and blood sugar stability

GLP-1 has been shown to be one of the two most important hormones (the other being GIP) to stimulate the incretin effect in rodent models

Despite this, only 6.9% of participants stopped treatment due to side effects, and the majority reported significant improvement by week four of each dose level