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Enteroendocrine cells (EECs) are specialized epithelial cells that are responsible for the release of a variety of gut hormones

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The overexpression of PFKFB3 has been found not only in cultured lung fibroblasts stimulated by inflammatory cytokines [35, 45, 50], but also in myofibroblasts from IPF patients [12] and in lung tissues from different animal models of pulmonary fibrosis [12, 50]

Investigating the synergistic effects of combining GLP-1 agonists, anti-inflammatory agents, and metabolic modulators could unlock new therapeutic strategies