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SUSTAIN-6: CDEC discussed the SUSTAIN-6 trial post hoc subgroup analysis of patients with T2DM, BMI of 27 kg/m 2 or greater, and established CVD as supportive evidence for the resubmission

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In addition: It is an inhibitory neurotransmitter which has recently been shown to support healthy neurological function* It is an important component necessary for healthy REM and delta sleep patterns* Glycine is especially helpful in improving the taste of Custom Amino Acids and Custom Vitamin/Mineral Formulas

A 2025 systematic review and meta-analysis of 23 randomized controlled trials found that berberine reduced body weight by an average of about 0.88 kg, or roughly 2 pounds