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Nevertheless, to date, nearly all reported STING antagonists necessitate frequent highdose intraperitoneal administration due to their rapid systemic clearance (for instance, H151 demonstrates a circulation halflife of less than 2 h after injection)

Atarashi K, Ishiyama A, Takagi M, Minami M, Kimura K, Goto A, Omata M

Nuclear receptor coactivator 4 (NCOA4) mediates ferritin degradation, causing iron release, and heme oxygenase-1 (HO-1) can catalyze the degradation of heme to produce iron to LIP [40]

The trade-off: Injections deliver the molecule most efficiently, but they dramatically raise the "risk floor" due to issues like sterility and systemic allergic responses