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SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells

Thus, NRF2 supports nucleotide biosynthesis through direct transcriptional mechanisms and by rewiring cellular metabolism to funnel metabolic intermediates into the pathways

In addition, they can also inhibit inflammation and oxidant-induced programmed cell death (e.g., apoptosis, necroptosis, pyroptosis) [64, 66, 67]

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