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Pre-clinical research conducted primarily in animal models informs the hypotheses for its use, but no large randomized controlled trials in humans have confirmed efficacy for any outcome - including gut-lining support, tissue-related processes, or any other claimed mechanism

When the conversion of propionyl-CoA to succinyl-CoA in the mitochondria fails due to Vitamin B 12 deficiency, elevated blood levels of methylmalonic acid (MMA) occur

Research shows this isn't true: While injections technically provide 100% delivery, sublingual sprays achieve nearly the same result without any of the drawbacks

However, not everyone absorbs vitamin B12 efficiently