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In addition, GLP-1 expression was down-regulated in wild-type Lox5 cells knocked out by FNDC5, and the induced expressions of lipolysis and autophagy-related genes and proteins were also inhibited, such as ATGL, HSL, and hepatic lipase deficiency gene (LIPC), suggesting that GLP-1 expression is also regulated by FNDC5, and may also provide therapeutic targets for lipid metabolism-related diseases

Lal is a speaker with Incyte, Sanofi, Pfizer, Abbvie, Boehringer Ingelheim, Sun Pharma, and Galderma

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Findings from the present study align with hypotheses [3] suggesting that mitochondrial energetic dysfunction may be involved in the pathophysiology of depression