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Cancer Res (2013) 73(12):370415

10.1523/JNEUROSCI.4703-13.2014 132

Everything else, from the shared gastrointestinal side-effect profile to the class boxed warning, largely travels across the family

The retatrutide triple agonist GLP-1 GIP glucagon mechanism works through three parallel axes: GLP-1 receptor activation: Stimulates glucose-dependent insulin secretion from pancreatic beta cells, suppresses glucagon release from alpha cells, slows gastric emptying, and reduces appetite signalling in the hypothalamus