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Chen C, Dong X, Zhang W, Chang X, Gao W (2024) Dialogue between mitochondria and endoplasmic reticulum-potential therapeutic targets for age-related cardiovascular diseases

doi:10.1212/WNL.0000000000005516 5

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Another strategy focuses on identifying and targeting specific metabolic dependencies, a concept referred to as metabolic vulnerability therapy. In cell subpopulations with elevated OXPHOS activity and glutamine-driven TCA cycle flux, the combined use of glutamine metabolism inhibitors such as CB-839 with oxidative stress inducers, including doxorubicin or isothiocyanates, markedly increases intracellular ROS levels