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Similarly, during the dose escalation phase of tirzepatide therapy, when gastrointestinal adverse effects are most common, temporary alcohol avoidance may be prudent until tolerance is established at the maintenance dose

ANOVA and Fishers least significant difference (LSD) test were used to compare differences among multiple groups

Aggregation occurs when reconstitution temperature was too high, injection was too forceful, or the peptide experienced temperature abuse during shipping

These findings strongly suggest that LAC deficits contribute to a depression-like state in mice, leading the scientists to wonder whether the molecule plays a similar role in humans