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In gouty arthritis, the intraarticular deposition of monosodium urate crystals activates the NLRP3 inflammasome, leading to the secretion of proinflammatory cytokines, including IL1, which mediate acute inflammatory responses

[68,69] This effect of GSH on skin pigmentation was reported half a century ago, with black human skin shown to exhibit lower levels of GSH than white skin

GPX4 helps to clear the toxic lipid hydroperoxides (LOOH), which prevents cellular damage from oxidative stress and maintains redox homeostasis [14], while the inhibition of GPX4 promotes lipid ROS-dependent ferroptosis

Clinical Effects of Si-Jun-Zi Decoction and Six-Ingredient Rehmannia Decoction on Qi-Yin Deficiency Chronic Kidney Disease