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Second, FIN56 binds to the enzyme squalene synthase, which leads to the depletion of endogenous antioxidant coenzyme Q10 (COQ10)

Mice were subjected to oral gavage of polystyrene microplastics with diameters of 0.5, 4, and 10 m for 28 days, resulting in bioaccumulation within testicular tissue, inflammatory responses, alterations in sperm morphology, impairment of testosterone biosynthesis, disruption of spermatogenesis, and weight reduction (110)

at E13.5, E14.5 and E15.5

45 In addition, FGF-19 dysregulation during alcohol consumption, and the resulting changes in bile acid synthesis and composition, may be contributing factors to ALD and gut flora dysbiosis