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Serious side effects are rare at recommended doses, but users should monitor for any unusual symptoms and consult healthcare providers if concerns arise

In vitro models to study confinement-induced responses include micropatterned lines [151], 2D micropatterned substrates [85], uni-axial compression [152], polydimethylsiloxane [153,154,155,156]- or polyacrylamide [90]-based microchannel devices, microniches [157, 158], and natural hydrogels [148, 159]

1,4 Early symptoms often include painful sensations, such as burning pain, electric shock-like sensations, sharp pains, and hyperalgesia