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This is a trend weve been seeing and its been seen by other studies as well that theres a shortage of these medications because its a much broader indication now than just diabetics its patients who are obese and dont have diabetes can get these medications, he told us

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Unlike traditional treatments that target only CSF production, GLP-1 agonists may work through two pathways: Weight loss - a major long-term treatment for IIH Possible CSF pressure effects - GLP-1 receptors on the choroid plexus (where CSF is made) may reduce fluid secretion independent of weight loss The IIH Pressure Trial ( Brain , 2023) found that exenatide lowered intracranial pressure within hours of the first dose

Moreover, degenerated IVDs contained more nerve fibers and the DRG neurons expressed painrelated neuropeptides that proposedly resulted in plasticity changes in the central nervous system, represented by the progressive astrocyte activation