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At this juncture, Phase II conjugation reactions, and in particular glutathione-dependent pathways are crucial, as they enable detoxification and promote the subsequent excretion of these reactive species

Testing prevents unnecessary procedures and targets treatment to those who truly need replacement

Activation AKT leads to accumulation of cytosolic -catenin and subsequent translocation to the nucleus where it forms a complex with TCF7L2 (139), a transcription factor that activates expression of Wnt target genes (242)