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A double-blind RCT (n=150) in patients receiving sagopilone chemotherapy showed no reduction in CIPN incidence with LC, although a slight decrease in severity was observed in ovarian cancer patients (not in prostate cancer patients)

"These drugs are thought to work by engaging part of the brain called the hypothalamus, which helps regulate a wide variety of hormones," said study co-author, Jena Shaw Tronieri, Senior Research Investigator at the Center for Weight and Eating Disorders at the University of Pennsylvania, in a press release

Thus, for each cycle, people with type 2 diabetes are at risk for MI, stroke, HF, ESKD and death, with the number experiencing each event in the cycle being tracked

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