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Specifically, microglia-derived IL-1, TNF, and complement component 1q activate astrocytes via the NF-B signaling pathway, resulting in reactive astrogliosis characterized by impaired neuronal support, reduced synaptic functions, and increased neuronal vulnerability [93]

Where present, it is referred to as Hutchinson's sign after the surgeon of that name noted it in the early historic accounts of subungual melanoma and referred to it as a "melanotic whitlow" conferring a poor prognosis

The specific activity was calculated after correction for the non-enzymatic reaction, and after normalization to the total protein content in each sample

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