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DPP-4 inhibitors mimic many of the actions ascribed to GLP-1 receptor agonists, including stimulation of insulin production and inhibition of glucagon secretion, and preservation of -cell mass by stimulating cell proliferation and inhibiting apoptosis [32]

Three different regions of interest of size 3232pixels for each image and a moving average of 10 was applied to avoid any artefacts due to cellular motion or very slow-moving particles