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In laboratory research, GHK-Cu is utilized in gene expression profiling experiments (documented effects on 4,000+ human genes), extracellular matrix research gene expression studies (collagen I, III, IV), matrix metalloproteinase (MMP-1, MMP-2, MMP-9) and TIMP regulation assays, glycosaminoglycan deposition measurements, decorin and integrin expression studies, superoxide dismutase (SOD) activity assays, and investigations of VEGF, FGF-2 expression modulation

A DerSimonian-Laird random-effects model was applied for the meta-analysis

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The mechanism behind the formation of these lesions is not well understood but is thought to be influenced by a number of factors